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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
36.97
Human Site:
S224
Identified Species:
50.83
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S224
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S224
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S224
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Dog
Lupus familis
XP_547091
832
93293
S452
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S224
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Rat
Rattus norvegicus
Q62673
603
68295
S224
Y
I
A
P
E
V
L
S
K
K
G
H
S
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
T121
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
Chicken
Gallus gallus
NP_001025810
595
66904
G214
Y
I
A
P
E
V
L
G
K
K
G
H
S
F
E
Frog
Xenopus laevis
P70032
598
68193
G215
Y
I
A
P
E
V
L
G
K
K
G
H
S
F
E
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
C210
Y
I
A
P
E
V
L
C
K
K
G
H
S
F
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
T196
Y
I
A
P
E
I
L
T
K
K
G
H
S
F
E
Honey Bee
Apis mellifera
XP_396707
575
66141
T194
Y
I
A
P
E
I
L
T
K
A
G
H
S
Y
E
Nematode Worm
Caenorhab. elegans
P34331
649
73615
N209
Y
I
A
P
E
V
L
N
K
A
G
H
S
F
E
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
S198
Y
I
A
P
E
V
L
S
K
K
G
H
S
Y
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
E207
Y
I
A
P
E
V
I
E
G
K
G
G
H
S
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
I84
A
S
R
T
K
I
Y
I
I
L
E
Y
I
T
G
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
M252
Y
I
A
P
E
V
L
M
G
K
H
S
G
H
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
93.3
93.3
93.3
N.A.
86.6
73.3
86.6
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
93.3
93.3
93.3
N.A.
100
93.3
93.3
100
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
53.3
N.A.
0
53.3
N.A.
P-Site Similarity:
N.A.
60
N.A.
20
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
6
0
89
0
0
0
0
0
0
12
0
0
0
0
0
% A
% Cys:
0
0
0
6
0
0
0
6
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
89
0
0
6
0
0
6
0
0
0
77
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
0
% F
% Gly:
0
0
6
0
0
0
0
12
12
0
83
12
6
0
6
% G
% His:
0
0
0
0
0
0
0
0
0
0
6
77
6
6
0
% H
% Ile:
0
95
0
0
6
18
6
6
6
0
0
0
6
0
0
% I
% Lys:
0
0
0
0
6
0
0
0
77
77
0
0
6
0
0
% K
% Leu:
0
0
0
0
0
0
83
0
6
12
0
0
0
0
0
% L
% Met:
0
0
0
0
0
6
0
6
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
89
0
0
0
0
0
0
0
0
0
6
6
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
6
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
6
6
0
0
0
0
0
42
0
0
0
6
77
6
6
% S
% Thr:
0
0
0
6
0
0
0
18
0
0
0
0
0
6
0
% T
% Val:
0
0
0
0
0
77
0
0
0
0
6
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
89
0
0
0
0
0
12
0
0
0
0
6
0
12
6
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _